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Marcos d'Ávila Nunes
University of Sao Paulo, Brazil
Applied Mathematics, Elementary Particle Physics, Biophysics, Accelerator Physics, Cryobiology, Physiology, Molecular Biology
- Protontherapy vs Carbon Ion Therapy - Advantages, Disadvantages and Similarities (no prelo)
Author: Nunes, M.A.
- Large Hadron Collider - Nova era de descobertas - Hadron Terapia
first 2013; Seven System International
- Hadron Therapy Physics and Simulations
first 2013; Springer. 8 editions in English.
- A saga de dois homens
first 2008; Biblioteca 24x7.
Development of a research software in Clipper for teaching trace elements in School of Medicine
WORLD CONGRESS ON MEDICAL PHYSICS ND BIOMEDICAL ENGINEERING., Nice, France; 1997
Trace elements in child health. New contribution to the study of oligoelements
Journal of te heart Institute - Piracicaba. 1997; 1 (4):9-17. (published)
Heart failure neonatal and Marfan Syndrome
Arquivo Brasileiro de Cardiologia. 1996; 67 (5):355-357. (published)
Cardiac evaluation in children with suspected heart disease. Preliminary results in 2000 patients
Journal of Pediatrics. 1995; 71 (4):209-213. (published)
Heart murmurs in children. Experience of a specialized clinic
Revista Paulista de Pediatria. 1995; 13 (2):39-41. (published)
Approach of te child with heart mumur.Importance of diagnostic based in complementary non-invasive exams
Arquivo Brasileiro de Cardiologia. 1995; 64 (3):195-199. (published)
Incidence of congenital heart defects in Down syndrome
Journal of Pediactrics. 1995; 71:28-30. (published)
Saturation transfer EPR spectroscopy applied to interactions between membrane proteins and cryoprotectants
WORLD CONGRESS ON MEDICAL PHYSICS AND BIOMEDICAL ENGINEERING., Rio de Janeiro, Brazil; 1994
Arquivos brasileiros de cardiologia. 12/1993; 61(5):273-8. (published)
PURPOSE--To determine the frequency and main features of subsequent cardiovascular surgery in patients operated on for coarctation of the thoracic aorta. METHODS--One hundred and five patients... [more]PURPOSE--To determine the frequency and main features of subsequent cardiovascular surgery in patients operated on for coarctation of the thoracic aorta. METHODS--One hundred and five patients operated on for coarctation of the aorta with a mean follow-up period of 14 years had their notes analysed. The patients were divided in 4 groups according to age at correction of the coarctation. The incidence of recoarctation repair and other cardiovascular operations were noted. RESULTS--Surgical morbidity was important: 33%. Recoarctation occurred in 14% of the cases, mainly in those who had the coarctation resected during the first year of life. Operation for other cardiovascular defects was necessary in 24.5% of the cases. Among these, correction of left-to-right shunts was done in 50% of the patients who had the coarctation resected in the first year of life. Relief of aortic stenosis was the most frequent procedure (73%), tends to be more frequent the other is the patient at coarctation repair and more than one procedure may be necessary in some cases. CONCLUSION--Reoperation is frequent in the long term of patients operated on for coarctation of the aorta. The elective coarctation should be repaired after the first year of life hoping to avoid recoarctation. Routine follow-up is advisable for all patients aiming to detect residual left-to-right shunts and left ventricular outflow tract obstruction. Family counseling regarding prognosis after coarctation resection is recommended.
Long-term follow-up after correction of coarctation of the aorta Subsequent surgical procedures
Arquivo Brasieiro de Cardiologia. 1993; 61:273-278. (published)
Nutritional index in Heart Diseases in Childhood
Arquivo Brasileiro de Cardiologia. 1991; 55:371-373. (published)
Arquivos brasileiros de cardiologia. 01/1991; 55(6):371-3. (published)
PURPOSE--To study heart disease in childhood aiming to know its incidence and consequences upon the nutritional status. PATIENTS AND METHODS--Two-hundred patients were distributed in three groups: 1)... [more]PURPOSE--To study heart disease in childhood aiming to know its incidence and consequences upon the nutritional status. PATIENTS AND METHODS--Two-hundred patients were distributed in three groups: 1) 113 (56.5%) with congenital acyanotic form; 2) 19 (9.5%) with congenital cyanotic form and 3) 68 (34%) with acquired forms. All of them regularly visiting the ambulatory service of Paediatric cardiology of the Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da USP from 1987 until 1990. RESULTS--The majority (92%) of the children (being 56% male and aging 5.1 +/- 0.4 years-old) showed nutritional indexes between 5 and 95 (percentile scale). The overall diagnosis distribution were: 1) ventricular septal defect (51 cases); 2) atrial septal defect (21 cases); 3) valvular diseases (21 cases); 4) arrhythmias (20 cases); 5) cardiac involvement of systemic diseases (20 cases); and 6) tetralogy complex (8 cases). Twelve patients (6%) were underscored (below percentile 5) and only 4 (2%) scored above percentile 95 (obese patients). The comparison of the mean indexes were found statistical different (p less than 0.05), being the cyanotic congenital forms the worst ones and the acquired forms the best one. CONCLUSION--Heart disease in childhood is associated to nutritional index deficits in the majority of the cases.
A new approach using ST EPR in analysis of membrane proteins-cryoprotectant interactions
Meeting satellite on Magnetic Resonance in Biological Materials, Saint Hughes College in Oxford, England; 1984
A new approach using saturation transfer electron paramagnetic resonance in analysis of membrane proteins-cryoprotectant interactions
VIII International Biophysics Congress, Bristol, England; 1984
The Journal of membrane biology. 02/1981; 60(2):155-62. (published)
Human erythrocytes were labeled with stearic acid spin labels, and no change was detected in membrane fluidity under hyperosmotic stress, going from isotonicity to about 3000 mOsm. Intact... [more]Human erythrocytes were labeled with stearic acid spin labels, and no change was detected in membrane fluidity under hyperosmotic stress, going from isotonicity to about 3000 mOsm. Intact erythrocytes labeled with an androstane spin label and submitted to simulation of freezing show the onset of irreversible structural breakdown occurring in a saline solution at 2,000 mOsm. Ghosts labeled with maleimide spin label (4-maleimide-2,2,6,6-tetramethylpiperidinooxyl) when submitted to solutions of increasing osmolalities (pH 7.4), exhibit protein conformational changes that are irreversible after a simulated freeze-thaw cycle. After sonication of maleimide spin-labeled ghosts, membrane buried sulfhydryl groups become exposed. Such preparations showed behavior similar to the unsonicated when in saline hyperosmolal medium (pH 7.4). Such results suggest the ionic strength of the medium as the determining factor of the detected conformational changes. Maleimide spin-labeled ghosts in 300 mOsm saline solution (pH 7.4) were treated with ascorbic acid (spin destruction of nitroxides), and the kinetic analysis indicates that 65% of the labeled sites are located at the external interface of the membrane or in hydrophilic channels. Deformation and rearrangements of membrane components in solutions of increasing osmolalities apparently are related to protein conformational changes, on the outside surface of erythrocyte membranes, with a significant amount being structurally dissociated of lipids.
Interactions between cryoprotectants and spin labeled erythrocyte membranes, during simulation of freezing
International Biophysics Congress and Pan-American Biochemistry III Congress, Mexico City, Mexico; 1981
Models for ultra-structure of biological membranes. Contributions of Electron Spin Resonance
first edited by Vieira,F.L. and Malnic, G., 1981: pages 64-85; Guanabara-Koogan.
A spin label study of erythrocyte membranes during simulation of freezing
The Journal of Membrane Biology. 1981; 60:155-162. (published)
Study of the flexibility gradient of phospholipids and protein conformational changes of human erythocytes submitted to simulation of freezing using electron paramagnetic resonance techniques
Physiology and Pharmacology, University of Sao Paulo, Institute of Biomedical Sciences, 1977
Degree: Full Professor
Permeability parameters of the toad isolated stratum corneum
The Journal of Membrane Biology. 1976; 27:251-264. (published)
A microelectrode suitable for the measurement of chloride concentration
Ref. No: Boston University and MIT
An electrometric method for rapid measurement of chloride concentration in small volumes
Biophysical Journal. 1975; 15:317. (published)
Negative potential level in the outer layer of the toad skin
The Journal of Membrane Biology. 1975; (published)
Electrophysiology of the outer layer of isolated frog skin
Physiology and Pharmacology, University of Sao Paulo, Institute of Biomedical Sciences, 1972
Degree: Doctoral thesis
Supervisor: Vieira, F.L.
COMMUNICATIONS IN CONGRESS: 49
35 (National Congress)
14 (International Congress)